As part of the ARPA-H Dash to Accelerate Heath Outcomes, Anuradha Lingappa, esq. from Prosetta makes an appearance on the #TalkPolymath Podcast to explain about our oncology program and how it feels to make it into the semifinals. Watch the whole video to learn about the other contestants and their technology, or skip to 32 minutes in to hear about Prosetta’s idea.

https://www.youtube.com/watch?v=kzyaSAdDTtA

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AuthorDmitry Temnikov

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Lingappa UF, Wu X, Macieik A, Yu SF, Atuegbu A, Corpuz M, Francis J, Nichols C, Calayag A, Shi H, Ellison JA, Harrell EK, Asundi V, Lingappa JR, Prasad MD, Lipkin WI, Dey D, Hurt CR, Lingappa VR, Hansen WJ, Rupprecht CE. Host-rabies virus protein-protein interactions as druggable antiviral targets. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E861-8. doi: 10.1073/pnas.1210198110. Epub 2013 Feb 12. PMID: 23404707; PMCID: PMC3593902.

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Broce S, Hensley L, Sato T, Lehrer-Graiwer J, Essrich C, Edwards KJ, Pajda J, Davis CJ, Bhadresh R, Hurt CR, Freeman B, Lingappa VR, Kelleher CA, Karpuj MV. Biochemical and biophysical characterization of cell-free synthesized Rift Valley fever virus nucleoprotein capsids enables in vitro screening to identify novel antivirals. Biol Direct. 2016 May 14;11:25. doi: 10.1186/s13062-016-0126-5. PMID: 27179769; PMCID: PMC4867995.

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Marreiros R, Müller-Schiffmann A, Trossbach SV, Prikulis I, Hänsch S, Weidtkamp-Peters S, Moreira AR, Sahu S, Soloviev I, Selvarajah S, Lingappa VR, Korth C. Disruption of cellular proteostasis by H1N1 influenza A virus causes α-synuclein aggregation. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6741-6751. doi: 10.1073/pnas.1906466117. Epub 2020 Mar 9. PMID: 32152117; PMCID: PMC7104400.

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AuthorDmitry Temnikov

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Reed JC, Solas D, Kitaygorodskyy A, Freeman B, Ressler DTB, Phuong DJ, Swain JV, Matlack K, Hurt CR, Lingappa VR, Lingappa JR. Identification of an Antiretroviral Small Molecule That Appears To Be a Host-Targeting Inhibitor of HIV-1 Assembly. J Virol. 2021 Jan 13;95(3):e00883-20. doi: 10.1128/JVI.00883-20. PMID: 33148797; PMCID: PMC7925099.

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Priyamvada L, Burgado J, Baker-Wagner M, Kitaygorodskyy A, Olson V, Lingappa VR, Satheshkumar PS. New methylene blue derivatives suggest novel anti-orthopoxviral strategies. Antiviral Res. 2021 Jul;191:105086. doi: 10.1016/j.antiviral.2021.105086. Epub 2021 May 13. PMID: 33992710.

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AuthorDmitry Temnikov

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Galli LM, Anderson MO, Gabriel Fraley J, Sanchez L, Bueno R, Hernandez DN, Maddox EU, Lingappa VR, Burrus LW. Determination of the membrane topology of PORCN, an O-acyl transferase that modifies Wnt signalling proteins. Open Biol. 2021 Jun;11(6):200400. doi: 10.1098/rsob.200400. Epub 2021 Jun 30. PMID: 34186010; PMCID: PMC8241489.

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AuthorDmitry Temnikov