After 6 rounds of voting, Prosetta’s submission to the ARPA-H Dash to Accelerate Health Outcomes, “One Drug for All Cancers” based on our Oncology Program emerges as the champion! Dr. Renee Wegrzyn, Head of ARPA-H, makes the announcement HERE
As part of the ARPA-H Dash to Accelerate Heath Outcomes, Anuradha Lingappa, esq. from Prosetta makes an appearance on the #TalkPolymath Podcast to explain about our oncology program and how it feels to make it into the semifinals. Watch the whole video to learn about the other contestants and their technology, or skip to 32 minutes in to hear about Prosetta’s idea.
Xavier Becerra (head of HHS, former Attorney General of California) announcing us as a semi-finalist
Click https://twitter.com/ARPA_H/status/1655967342525026304 to see the tweet
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Preprint of Prosetta’s Oncology Manuscript, “Small Molecule Assembly Modulators with Pan-Cancer Therapeutic Efficacy” Available on Biorxiv
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Prosetta’s oncology program was featured in the Cancer Moonshot issue of the Life Sciences Insights magazine
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Lingappa UF, Wu X, Macieik A, Yu SF, Atuegbu A, Corpuz M, Francis J, Nichols C, Calayag A, Shi H, Ellison JA, Harrell EK, Asundi V, Lingappa JR, Prasad MD, Lipkin WI, Dey D, Hurt CR, Lingappa VR, Hansen WJ, Rupprecht CE. Host-rabies virus protein-protein interactions as druggable antiviral targets. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E861-8. doi: 10.1073/pnas.1210198110. Epub 2013 Feb 12. PMID: 23404707; PMCID: PMC3593902.
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Broce S, Hensley L, Sato T, Lehrer-Graiwer J, Essrich C, Edwards KJ, Pajda J, Davis CJ, Bhadresh R, Hurt CR, Freeman B, Lingappa VR, Kelleher CA, Karpuj MV. Biochemical and biophysical characterization of cell-free synthesized Rift Valley fever virus nucleoprotein capsids enables in vitro screening to identify novel antivirals. Biol Direct. 2016 May 14;11:25. doi: 10.1186/s13062-016-0126-5. PMID: 27179769; PMCID: PMC4867995.
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Galli LM, Zebarjadi N, Li L, Lingappa VR, Burrus LW. Divergent effects of Porcupine and Wntless on WNT1 trafficking, secretion, and signaling. Exp Cell Res. 2016 Sep 10;347(1):171-183. doi: 10.1016/j.yexcr.2016.07.028. Epub 2016 Aug 1. PMID: 27492485; PMCID: PMC5032901.
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Marreiros R, Müller-Schiffmann A, Trossbach SV, Prikulis I, Hänsch S, Weidtkamp-Peters S, Moreira AR, Sahu S, Soloviev I, Selvarajah S, Lingappa VR, Korth C. Disruption of cellular proteostasis by H1N1 influenza A virus causes α-synuclein aggregation. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6741-6751. doi: 10.1073/pnas.1906466117. Epub 2020 Mar 9. PMID: 32152117; PMCID: PMC7104400.
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Lingappa JR, Lingappa VR, Reed JC. Addressing Antiretroviral Drug Resistance with Host-Targeting Drugs-First Steps towards Developing a Host-Targeting HIV-1 Assembly Inhibitor. Viruses. 2021 Mar 10;13(3):451. doi: 10.3390/v13030451. PMID: 33802145; PMCID: PMC8001593.
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Müller-Schiffmann A, Trossbach SV, Lingappa VR, Korth C. Viruses as 'Truffle Hounds': Molecular Tools for Untangling Brain Cellular Pathology. Trends Neurosci. 2021 May;44(5):352-365. doi: 10.1016/j.tins.2020.11.004. Epub 2020 Dec 11. PMID: 33317827.
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Reed JC, Solas D, Kitaygorodskyy A, Freeman B, Ressler DTB, Phuong DJ, Swain JV, Matlack K, Hurt CR, Lingappa VR, Lingappa JR. Identification of an Antiretroviral Small Molecule That Appears To Be a Host-Targeting Inhibitor of HIV-1 Assembly. J Virol. 2021 Jan 13;95(3):e00883-20. doi: 10.1128/JVI.00883-20. PMID: 33148797; PMCID: PMC7925099.
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Priyamvada L, Burgado J, Baker-Wagner M, Kitaygorodskyy A, Olson V, Lingappa VR, Satheshkumar PS. New methylene blue derivatives suggest novel anti-orthopoxviral strategies. Antiviral Res. 2021 Jul;191:105086. doi: 10.1016/j.antiviral.2021.105086. Epub 2021 May 13. PMID: 33992710.
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Galli LM, Anderson MO, Gabriel Fraley J, Sanchez L, Bueno R, Hernandez DN, Maddox EU, Lingappa VR, Burrus LW. Determination of the membrane topology of PORCN, an O-acyl transferase that modifies Wnt signalling proteins. Open Biol. 2021 Jun;11(6):200400. doi: 10.1098/rsob.200400. Epub 2021 Jun 30. PMID: 34186010; PMCID: PMC8241489.
Click www.biorxiv.org for the full article.
Click here for a nontechnical summary of the program.
Prosetta recently got a mention in a Nature Medicine Article: Host with the most: Targeting host cells instead of pathogens to fight infectious disease.
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Takeda Pharmaceutical will partner with Prosetta Biosciences on a feasibility study for possible future co-development of Prosetta’s novel compounds for diseases and disorders of the central nervous system. Read more here.